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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WIPF1 All Species: 27.27
Human Site: S436 Identified Species: 50
UniProt: O43516 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43516 NP_001070737.1 503 51275 S436 P P P P P S T S I R N G F Q D
Chimpanzee Pan troglodytes XP_001150374 510 51924 S436 P P P P P S T S I R N G F Q D
Rhesus Macaque Macaca mulatta XP_001090880 510 52064 S436 P P P P P S T S I R N G F Q D
Dog Lupus familis XP_545531 517 52682 S450 P P P P P S T S I R N G F Q D
Cat Felis silvestris
Mouse Mus musculus Q8K1I7 493 50062 S426 P P P P P S T S V R N G F Q D
Rat Rattus norvegicus Q6IN36 487 49732 S420 P P P P P S T S V R N G F Q D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515714 498 50998 S431 P P P P P S S S I R N G F Q D
Chicken Gallus gallus NP_001012935 494 49866 A427 P P P P P P S A A L R N G F Q
Frog Xenopus laevis NP_001079978 426 44520 P367 P S G P P P P P P P V R N G M
Zebra Danio Brachydanio rerio XP_001919866 485 49016 G421 P P P P A P I G N G Y H S Q H
Tiger Blowfish Takifugu rubipres NP_001098701 410 41639 N351 G F Q N S H H N Q I Q D E W E
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001195725 392 41038 P332 R S P P A R N P P A R D S G I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37370 817 82575 Q458 K P S A S S K Q S K I S S S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 96.6 85.8 N.A. 88.6 87.4 N.A. 80.9 73.1 40.5 58.6 39.3 N.A. N.A. N.A. 35.9
Protein Similarity: 100 98.2 97.6 90.3 N.A. 92 91.6 N.A. 87.2 82.1 50.5 68.1 48.3 N.A. N.A. N.A. 42.5
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 33.3 20 33.3 0 N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 46.6 20 33.3 13.3 N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 16 0 0 8 8 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 16 0 0 54 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 0 54 8 0 % F
% Gly: 8 0 8 0 0 0 0 8 0 8 0 54 8 16 0 % G
% His: 0 0 0 0 0 8 8 0 0 0 0 8 0 0 8 % H
% Ile: 0 0 0 0 0 0 8 0 39 8 8 0 0 0 8 % I
% Lys: 8 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 8 0 0 8 8 8 0 54 8 8 0 0 % N
% Pro: 77 77 77 85 70 24 8 16 16 8 0 0 0 0 0 % P
% Gln: 0 0 8 0 0 0 0 8 8 0 8 0 0 62 8 % Q
% Arg: 8 0 0 0 0 8 0 0 0 54 16 8 0 0 0 % R
% Ser: 0 16 8 0 16 62 16 54 8 0 0 8 24 8 8 % S
% Thr: 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 16 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _